37215 - 壓痛儀
壓痛儀根據(jù)Randall-Selitto理論設(shè)計(jì)，是進(jìn)行壓爪實(shí)驗(yàn)的經(jīng)典儀器。實(shí)驗(yàn)時(shí)，將嚙齒類動(dòng)物的爪置于圓柱形底座，操作員踩壓腳踏板，其上方的圓錐形推進(jìn)器往爪上施力。當(dāng)受試動(dòng)物開(kāi)始掙扎時(shí)，操作員松開(kāi)腳踏板板，讀取刻度值，其表示受試動(dòng)物的疼痛值。壓痛儀的顯著特征是配備了一個(gè)低電壓同步電動(dòng)機(jī)。
現(xiàn)在也有可用于小鼠的版本37216，壓力值降低50%，另新增一個(gè)推桿。
| 特征 | 優(yōu)點(diǎn) |
| 基于力學(xué)原理的壓力增強(qiáng)設(shè)計(jì) | 持久可靠，不需校準(zhǔn) |
| 壓力增強(qiáng)范圍 (0-750 g) | 可用于發(fā)炎和非發(fā)炎的爪 |
| 雙面壓力頭 (鈍、錐形) | 用于不同實(shí)驗(yàn) |
規(guī)格
| 大力值: | 750 g |
| 力增加速率: | 16 g/s (加一個(gè)砝碼時(shí)為16x2 g/s, 加兩個(gè)砝碼時(shí)為16x3g/s) |
| 刻度分辨率: | 5 g (加一個(gè)砝碼時(shí)為5x2g, 加兩個(gè)砝碼時(shí)為5x3g) |
| 電源要求： | 115或230V，50/60 Hz，大15 W |
附件：
與電腦兼容：
可選配2600 CUB software
參考文獻(xiàn)：
關(guān)于方法
· L.O. Randall and J.J. Selitto: “A Method for Measurement of Analgesic Activity on Inflamed Tissue” Arch. Int. Pharmacodyn. CXI, No. 4: 409-419, 1957.
涉及壓痛儀（大鼠）
· K. Walker et alia: “The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain“ J. Pharmacol. Exper. Therap. 304, No. 1: 56-62, 2003.
· S. Asfaha et alia: “Proteinase-Activated Receptor-1 Agonists attenuate nociception in Response to Noxious Stimuli“ Br. J. Pharmacol. 135: 1101-1106, 2002.
· K.O. Aley et alia: “Chronic Hypersensitivity for Inflammatory Nociceptor sensitization Mediated by the ?Isozyme of Protein Kinase C“ J. Neuroscience 20 (12): 4680-4685, 2000.
· O.A. Kochuvelikakam and J.D. Levine: “Role of Protein Kinase A in the Maintenance of Inflammatory Pain“ J. Neuroscience. 19(6): 2181-2186, 1999.
涉及壓痛儀（小鼠）
· H. Saegusa et alia: “Suppression of Inflammatory and Neuropathic Pain Symptoms in Mice Lacking the N-type Ca2+ Channel“ The EMBO Journal. 20, No. 10: 2349-2356, 2001.
· W. Binder et alia: “Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two К-Opioids“ J. Pharmacol. Exper. Therap. 292: 303-309, 2000.
